To determine whether either of two magnetic resonance imaging approaches - delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC), or T2 mapping - can detect short-term changes in knee hyaline cartilage among individuals taking a formulation of collagen hydrolysate.
dGEMRIC, or delayed gadolinium-enhanced MRI of cartilage is a technique that can be used quantitatively to assess glycosaminoglycan content of cartilage or qualitatively to asses the overall structures of cartilage. When the technique is adapted and applied to menisci it is called dGEMRIM. Delayed contrast-enhanced MRI of cartilage (dGEMRIC) is a noninvasive technique to study cartilage glycosaminoglycan (GAG) content in vivo. This study evaluates dGEMRIC in patients with preradiographic degenerative cartilage changes.
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dGEMRIC technique for the hip corre-. Apr 10, 2007 The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) its compressive strength and the dGEMRIC technique uses a negatively Jul 24, 2020 cartilage (dGEMRIC) is a validated MRI technique for detecting early MRI techniques such as T1ρ and T2 mapping have also been shown relaxation mapping of the knee joints of both hind legs. The delayed gadolinium- enhanced MR imaging of cartilage (dGEMRIC) and iGEMRIC techniques were. BACKGROUND: Delayed Gadolinium Enhanced Magnetic Resonance Imaging of Cartilage.
Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was first described in 1996 as a nondestructive technique for quantitative measurements of glycosaminoglycan (GAG) concentration in articular cartilage samples .Its translation to clinical platforms as a means of interrogating the molecular aspects of cartilage was demonstrated in 1997 with illustrative examples of apparent …
Thus the dGEMRIC technique has a potential to detect early cartilage damage, which in turn is very helpful to clinicians for critical decision making regarding timely intervention for therapy. This review outlines the current status of dGEMRIC and technical considerations specific to dGEMRIC for assessment of hip joint cartilage. To Lund University Lund University Libraries Book a seat in the Special Collections Reading Room FAQ Opening hours Current students New students International Desk Academic matters & support IT services & support Careers Service Sweden stands up for open access – cancels agreement with Elsevier LUBcat LIBRIS MRI of Cartilage (dGEMRIC) technique. [2, 3] into our routine clinical imaging protocol.
2011-11-24 · The dGEMRIC index has been validated against histologic and biochemical measurements of glycosaminoglycan content in clinical studies . dGEMRIC has potential as a non-invasive technique for monitoring the glycosaminoglycan content of cartilage after repair by various techniques (Figure 6).
These series of images are then post-processed to obtain the T1 maps (14). Fast T1 mapping techniques such as the Look-Locker (15) and DESPOT (16) techniques are available. 2020-12-01 · The dGEMRIC technique and study protocol have been validated , and clinically relevant associations between the dGEMRIC and risk factors for OA have been presented [27, 28]. The dGEMRIC technique has also proved to have a prognostic value for OA development [29,30,31]. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), after slipped capital femoral epiphysis. Zilkens C(1), Miese F, Bittersohl B, Jäger M, Schultz J, Holstein A, Kim YJ, Millis MB, Mamisch TC, Krauspe R. Author information: (1)Department of Orthopaedics, Heinrich-Heine University Medical School, Duesseldorf, Germany. Local Flip Angle Correction for Improved Volume T1-Quantification in Three-Dimensional dGEMRIC Using the Look-Locker Technique Siversson, Carl LU; Tiderius, Carl Johan LU; Dahlberg, Leif LU and Svensson, Jonas LU () In Journal of Magnetic Resonance Imaging 30 (4).
T1 - Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases. AU - Zilkens, Christoph. AU - Tiderius, Carl Johan.
Other, less-validated methods for quantifying cartilage . 2011-06-29 Will be measured using the delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) technique Lumbar lordosis angle [ Time Frame: Baseline: before surgery ] Will be measured by the EOS imaging system.
Using this technique, the distribution of Gd-(DTPA)2−contrast agent in cartilage after intravenous injection is assessed with quantitative T1
Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases Zilkens, Christoph; Tiderius, Carl Johan LU; Krauspe, Ruediger and Bittersohl, Bernd () In Skeletal Radiology 44 (8). p.1073-1083.
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The method is robust, but requires injection of contrast agent and a cumbersome examination procedure. The most straightforward application of dGEMRIC or any molecular imaging technique is simply to demonstrate and follow “lesions” in otherwise apparently normal-appearing cartilage. Detection and monitoring of these lesions demonstrate a number of paradigm-changing concepts in the evaluation of cartilage physiology and pathophysiology. To determine the feasibility of using a high resolution isotropic three‐dimensional (3D) fast T1 mapping sequence for delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) to assess osteoarthritis in dGEMRIC technique uses either a two-dimensional (2D) or 3D spin-echo inversion recovery or saturation recovery sequence with varying inversion time (TI) or repetition time (TR).
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What Is the Correlation Among dGEMRIC, T1p, and T2* Quantitative MRI Cartilage Mapping Techniques in Developmental Hip Dysplasia? Melkus, Gerd PhD
These limitations are not inherent to the technique but rather are due to the limitations in T1 mapping technique and software. 2021-03-19 · The dGEMRIC technique is quite complex because several factors can have influence, among them the body mass index, degree of physical activity, and variations in time between injection of contrast agent and imaging. 66,67 The dGEMRIC technique has provided valuable results in studies on hip dysplasia , in comparative studies with arthroscopically determined cartilage softening in early osteoarthritis , and demonstrated the positive effects of moderate exercise on GAG content in knee cartilage .